![]() ![]() 31, 20, includes $89.7 million and $33.0 million, respectively of upfront and milestone payments related to license and collaboration agreements.įourth Quarter and Recent Company Highlights ![]() Adjusted EBITDA and non-GAAP net income for the years ended Dec. 31, 20, includes $36.2 million and $30.0 million, respectively of upfront and milestone payments related to license and collaboration agreements. Adjusted EBITDA and non-GAAP net income for the three months ended Dec. We expect another year of strong double-digit net sales and adjusted EBITDA growth in 2022, as well as meaningful margin expansion, as we continue to execute commercially and build on our momentum in R&D to develop new approaches for patients with rare, autoimmune and severe inflammatory diseases.”įinancial Highlights (in millions except for per share amounts and percentages)īeginning in the fourth quarter of 2021, the Company no longer excludes upfront and milestone payments related to license and collaboration agreements from non-GAAP financial measures. “I am very proud of what we have accomplished, but I am most excited about the potential for continued growth going forward as we leverage the strong foundation we have built over the past several years. “2021 marked a year of tremendous growth for Horizon – we invested significantly in our research and development capabilities and talent, significantly expanded our pipeline, increased our manufacturing capacity to meet growing demand and achieved outstanding financial results,” said Tim Walbert, chairman, president and chief executive officer, Horizon. ![]() 1, 2022- Horizon Therapeutics plc (Nasdaq: HZNP) today announced fourth-quarter and record full-year 2021 financial results and provided full-year 2022 net sales and adjusted EBITDA guidance. Advanced Pipeline to Drive Long-Term Growth Entered into Agreement with Alpine toĭevelop Novel Therapies for Autoimmune and Inflammatory Diseases -ĭUBLIN-(BUSINESS WIRE)-Mar. FDA to Expand Label for KRYSTEXXA to Include Co-Treatment with Methotrexate Based on Positive Data from MIRROR Trial. Submitted S upplemental Biologics License Application (sBLA) to the U.S. Initiated Four Clinical Trials, Including TEPEZZA Phase 3 Trial in Japan. Expect KRYSTEXXA Net Sales Growth of More Than 20%. Expect TEPEZZA Net Sales Percentage Growth in the Mid-30s. Adjusted EBITDA Guidance of $1.63 Billion to $1.70 Billion, Representingģ0% Growth and 230 Basis Points of Margin Expansion at the Midpoint. Net Sales Guidance of $3.9 Billion to $4.0 Billion, Representing 22% Growth at the Midpoint. Operating Cash Flow of More Than $1.0 Billion. Record KRYSTEXXA Net Sales of $565.5 Million, Representing Year-Over-Year Growth of 39%. Record TEPEZZA Net Sales of $1.66 Billion, Representing Year-Over-Year Growth of 103%. GAAP Net Income of $534.5 Million Adjusted EBITDA of $1.28 Billion. Record Net Sales of $3.23 Billion Increased 47%. Cash Position of $1.58 Billion as of Dec. KRYSTEXXA Plus Immunomodulation Use Now Approaching 50%. KRYSTEXXA ® (pegloticase injection) Net Sales of $170.3 Million Increased 32% TEPEZZA ® (teprotumumab-trbw) Net Sales of $589.6 Million Increased 72%. GAAP Net Income of $173.2 Million Adjusted EBITDA of $416.0 Million. Net Sales of $1.01 Billion Increased 36%. ![]()
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![]() ![]() Follow the hyperlink for ako listed at the top of page. What is army knowledge online? Accessing your ako email login. The army's enterprise portal, army knowledge online (ako), is a . This list is build manually with all the relevant results available on the web. You can sign into ako without a cac/piv, but information marked fouo is not . Ako (army knowledge online) Why can't i log into amid (army management identification) with my cac? Select the set cac only . Why can't i log into amid (army management identification) with my cac?Īrmy knowledge online manages email for . Army knowledge offline is a link hub for most u.s. ![]() Why can't i log into amid (army management identification) with my cac? Accessing your ako email login. What is army knowledge online? Open the my account menu. How To Access Ako From Home Bikehike from i. Army knowledge online manages email for . Log in to your ako account using your cac. Ako (army knowledge online) Select the set cac only . 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Pay for the full version, if you’re not broke.” All reviews How to play MKV on Mac using Elmedia Player I can’t remember the things about this app that aren’t perfect, or to my precise liking, so… They’re unimportant details, I guess. it was so good, i eventually paid for the full version! i gave it 4 stars because i feel that 5 stars is a perfect score, and not very many things are perfect. And the key commands (or “smart keys”) are familiar and sensible. It has everything you need in order to enjoy your media. “This player is really good - it reminds me of VLC in a lot of ways… but its free version is nearly perfect. The app’s Pro features include streaming local files via AirPlay 2, DLNA, or Chromecast. Elmedia comes with a clean and intuitive interface, integrated with your Mac’s touch bar gestures. There is a video tuner to set brightness, saturation, contrast, gamma, etc., as well as an audio equalizer. The app then allows you to adjust the playback and sound properties. ![]() Elmedia doesn’t require you to download additional codecs or plugins. Thanks to its wide range of supported formats, it will open any video or audio content on your device. Elmedia PlayerĮlmedia Player is a top choice when it comes to playing MKV files on Mac. Read below to learn about their features, pros & cons, and how they work. They fully support the MKV file format and open it directly. In that case, the versatile solutions proposed below can even resolve several issues at once. This approach is suitable for users who are not comfortable with installing extra codecs and plugins, or are unhappy with more than one aspect of QuickTime Player. There are a number of great apps you can use to open an MKV file on Mac. How do I play MKV files on my Mac 2023?.What to do if I can’t play MKV on Mac properly?.Method 3.One of the Outdated Methods Perian Plugin.Сonverting Your MKV File Into a Format Compatible with macOS ![]() ![]() ![]() Over his nine years of experience covering the audiovisual industry, Steven has reviewed numerous TVs, headphones, speakers, monitors, streaming players, and more. He previously served as High-Def Digest's Gear Editor from 2013 to 2019, and his work has appeared on Ben's Bargains, Steve's Digicams, Big Picture Big Sound, and Consequence of Sound. Steven is a Tech Editor for the Insider Reviews team, where he oversees streaming and home entertainment product coverage. Subscriptions usually cost $40 a month, but new members can get their first month for a discounted rate of $30. Sling's Orange plan includes ESPN, along with 30 other popular channels. Sling TV is the cheapest service to live stream the game. If you don't already have a pay-TV provider with access to ESPN, you can sign up for a live TV streaming service like Sling TV, Hulu + Live TV, or FuboTV to watch the Lakers vs. Nuggets tonight on ESPN through cable, satellite, and any live TV streaming service that carries the channel. ![]() Start time: Game Two begins at 8:30 p.m.Watch from anywhere: Use ExpressVPN to stream from Sling TV.US: ESPN via Sling Orange ( $40 $30 for the first month).ET tonight and we have all the links and channel info right below. ![]() It doesn't take long to get a VPN up and running and it'll help unlock global streaming options and greatly enhance your privacy and general security across your devices.ĭenver leads the best-of-seven series 1-0 and will want to take another home win before hitting the road for Game Three in LA on Saturday. Better yet, if you're outside the US right now, we can help you tune in from anywhere in the world via a VPN. It's time for Game Two of the Western Conference Finals and we have everything you need on how to watch the Lakers vs Nuggets live stream. ![]() ![]() If you see inaccuracies in our content, please report the mistake via this form. If we have made an error or published misleading information, we will correct or clarify the article. Close all your programs and then click on the Finder menu. 2.) Open up Disk Utility (Applications > Utilities) and select your flash drive on the list to the left. Our editors thoroughly review and fact-check every article to ensure that our content meets the highest standards. Finder > Preferences > General Tab > check External disks View in context Helpful dwb Level 7 32,853 points 12:34 PM in response to ashrose721 You probably don't have your computer set to show drives on the desktop. Our goal is to deliver the most accurate information and the most knowledgeable advice possible in order to help you make smarter buying decisions on tech gear and a wide array of products and services. ZDNET's editorial team writes on behalf of you, our reader. After the download tool completes the ISO download, do any of the following: Use the ISO file to create a bootable USB (you can use the free tools available online). ![]() Indeed, we follow strict guidelines that ensure our editorial content is never influenced by advertisers. Table of Contents Connect and use other storage devices with Mac External hard drives, thumb drives, USB drives, and Flash memory cards are examples of storage devices that you can connect to your Mac using Thunderbolt, USB, or USB-C cables, or connect wirelessly using Bluetooth wireless technology. To do so, click the account icon (its on the top-right menu corner) click 'Downloads' click 'Bootable media'. Chose one between the two options given below based on your own situation and click Start. In the pop-up window, click Check under Tools tab. Neither ZDNET nor the author are compensated for these independent reviews. In File Explorer, right-click the USB flash drive and choose Prosperities. Also, check the visibility of the external drive. This helps support our work, but does not affect what we cover or how, and it does not affect the price you pay. Try using a different USB port on your Mac, change the USB cable, or connect the storage device to another Mac. When you click through from our site to a retailer and buy a product or service, we may earn affiliate commissions. And we pore over customer reviews to find out what matters to real people who already own and use the products and services we’re assessing. Make sure that your external drive doesn’t become damaged in the future by always unmounting the disk properly after using it. We gather data from the best available sources, including vendor and retailer listings as well as other relevant and independent reviews sites. We have final suggestion to make that is more of a guard against this error happening again. ![]() The flash drive will appear as an icon on the desktop, or on the left-hand menu of the Finder window. ZDNET's recommendations are based on many hours of testing, research, and comparison shopping. Connect your USB drive within the USB port on your Mac, this will vary in location depending on the model and may be on the side or back of the machine. ![]() ![]() ![]() The Viewsonic LS810 is considered as the best projector available in the market today. This kind of projector is an ideal choice for people who do not want to spend too much money on the purchase of a new television set or a brand new system to watch videos. Thus you will not have to worry about getting distorted images when you watch your favorite movies or videos. The technology incorporated in this projector is such that you get excellent clarity throughout. With the help of this, you can also watch high definition videos and movies in a better way. This projector offers a great clarity and color clarity and thus is well worth its price. The Best 8k Projector from Optoma is a dual screen system and thus offers you better quality images than other similar models in the market. These projectors are quite impressive and provide high definition visuals with the help of state of the art technology. If this will be in your living room, higher is better.Optoma designed and produced the Best 8k Projector for you which not only gives a clear picture and crisp image, but also helps you save money on the purchase. If you plan on adorning a dark home theater, you can get away with a lower number. Dim projectors can project just fine in the dark, but it takes high lumens to cast a crisp picture in a bright room. ![]() This mainly comes into play when you have well-lit rooms. The higher the lumens, the brighter the picture. Lumens - Lumens determine how bright the projector's light is. You want the first number to be as high as possible. The contrast ratio will be in the form of a number:1, like 1,000:1 or 1,000,000:1. This is important because it allows your projector to display a full range of colors without getting too grainy or washed out. The lower resolution, the more boxy your image will be.Ĭontrast Ratio - The contrast ratio is determined by the difference in color between the brightest brightness a projector can achieve and the darkest black. Resolution - Like a TV, your projector's resolution determines how sharp and clear your picture will be. All the same, our reviewer considers it a minor issue, but still one worth mentioning. During normal use, it's hard to see, but in our testing, it became pretty clear. One minor issue is a slight variance in luminance from edge to edge of the screen. That's a ton of coverage and versatility, meaning you can use this projector in any tight space, including a bedroom or a dorm room. This is a short-throw projector, which means it can fill up to a 100-inch screen from just under 5 feet away. But most of all, this projector was built for gaming, with low-input lag from your game system and controllers. Plus, the 2,200 lumens will work in just about any room, even one that sees light from the outside. This projector boasts a 15,000:1 contrast ratio for great detail in darker scenes. If you want to get your game on in high resolution, the BenQ HT2150ST is for you. Movies and boardroom presentations aren't the only use for projectors. ![]() Given its price, we consider that to be an acceptable compromise, but if you're a competitive gamer, you'll want something with much lower latency. If you're not into online gaming or battle royales, that probably won't make much of a difference to you. Single-player games run just fine, but when you get into a multi-player setting, and especially a competitive setting, the 50ms of input lag can affect your overall performance. Maybe that won't bother you if you have a few extra seconds on each end, but we also noted a bit of lag when it comes to gaming. Unfortunately, slow is a bit of a theme for this projector, since our tester also noted slow boot-up and shut-down times. Our tester found that its 2,200 lumens were quite bright enough for broad daylight, which can be challenging for many projectors. The BenQ is a great 4K find at just under $1,500, which is really low for a 4K projector. It's tuned in the factory for the best color output you can find, and it shows right out of the box. This projector offers truly great color accuracy. BenQ makes really great projectors, and that's true here in the BenQ HT3550. ![]() ![]() ![]() “Dealing with backstabbers, there was one thing I learned. As if there’s a ‘one size fits all’ standard for happiness.” “I refuse to accept other people’s ideas of happiness for me. “I think my first album opened a lot of doors for me to push the freedom of speech to the limit.” “When you seek to do something, if you don’t know the whole game plan, you’re usually going to work against yourself.” “Sporadic thoughts will pop into my head and I’ll have to go write something down, and the next thing you know I’ve written a whole song in an hour.” “Usually, when I’m rappin’, I’m creating a big story or a concept song that sounds like a movie to me.” ![]() “In the future, hip-hop is going to be called American folklore.” “Keep your nose out the sky, keep your heart to god, and keep your face to the rising sun.” I think people should respect artists, and there should be a certain respect for artists who give their music away for free.” I think all communication should be free. It’s the only thing I’ve ever been even decent at. You may take a rhyme pattern or flow from Big Daddy Kane or Kool G Rap.” “Being a student of hip-hop in general, you take technical aspects from places. Second albums, man, they’re even scarier than first ones.” “I didn’t want to play it boring and safe. “Nothing in life is promised except death.” Within four, eight bars of it playing I’m just like, ‘Oh, OK. ![]() Usually when the beat comes on, I think of a hook or the subject I want to rap about almost instantly. “The writing process, the way I go about it is I do whatever the beat feels like, whatever the beat is telling me to do. “Hip-hop is supposed to uplift and create, to educate people on a larger level and to make a change.” “You might win some, but you just lost one.” “Sometimes I feel like rap music is almost the key to stopping racism.” ![]() The next you can put pen to paper, write a song, and create art in such little time! It’s crazy beautiful.” “One minute you’re an amateur, knowing nothing, not even the basics. “99 Problems is almost a deliberate provocation to simpleminded listeners.” “I would have so many friends if I help back the truth and just gave out compliments.” “I’m gonna show the most graphic details of what I see in my community and hopefully they’ll stop it quick.” Kim and I were always either getting evicted or our house was getting shot up or robbed.” Because really, what was I going to do with my life? I had a young daughter. “Rap was always a pipe dream for me, but rap was all I had. “Hip-hop is what makes the world go around.” “Surround yourself with love, not friends.” “I am a hard person to love but when I love, I love really hard.” “When the devil wants to dance with you, you better say never, because the dance with the devil might last you forever.” “I never sleep, cause sleep is the cousin of death.” “Life without knowledge is death in disguise.” “I’ve been hated by many, wanted by plenty, disliked by some, but confronted by none.” “A poet’s mission is to make words do more work than they normally do, to make them work on more than one level.” To help you save a lot of time, we have collected some of the most profound and legendary rapper quotes of all time.Įnjoy reading! Here’s our selection of inspirational and deep rapper quotes 1. While there are many rap songs out there that leave absolutely no impression, you can come across some true masterpieces by a brilliant artist every once in a while. It can raise awareness of social problems or set the right chill-out ambiance with thoughtful rhymes underlined by soothing beats just as much as it can kickstart a great party.īut not every lyric is the same. Rap music is one of the most versatile music genres out there. From the iconic MCs who started spitting the very first lyrics of rap music to the present day household names, they all contributed iconic pieces to hip-hop’s rise to popularity. Whether a Hall of Famer or not, every single rap artist has brought a distinct style and a creative fusion of lyrics, tonality, and beats to the genre. Enjoy this selection of legendary rapper quotes ![]() ![]() ![]() Each file type has a slighty different installation procedure to follow.įor more help, visit our Driver Support Page for step-by-step videos on how to install drivers for every file type. For example, you may have downloaded an EXE, INF, ZIP, or SYS file. Tech Tip: Driver downloads and updates come in a variety of file formats with different file extensions. In most cases, you will need to reboot your computer in order for the driver update to take effect. Locate the device and model that is having the issue and double-click on it to open the Properties dialog box.Ĭlick the Update Driver button and follow the instructions. How to Install a driver from Device Manager In Windows XP, click Start -> Control Panel -> Performance and Maintenance -> System -> Hardware tab -> Device Manager button In Windows Vista, click Start -> Control Panel -> System and Maintenance -> Device Manager In Windows 7, click Start -> Control Panel -> Hardware and Sound -> Device Manager and selecting the Logitech Gaming Software app), or from the Windows 7 (or previous) Start menu, choose All programs Logitech Logitech Gaming Software, or double-click the icon in the Windows taskbar (or right-click it and select Open from the pop-up menu). In Windows 8, swipe up from the bottom, or right-click anywhere on the desktop and choose "All Apps" -> swipe or scroll right and choose "Control Panel" (under Windows System section) -> Hardware and Sound -> Device Manager In Windows 11, Windows 10 & Windows 8.1, right-click the Start menu and select Device Manager In Windows, use a built-in utility called Device Manager, which allows you to see all of the devices recognized by your system, and the drivers associated with them. Once you have downloaded your new driver, you'll need to install it. Most major device manufacturers update their drivers regularly. To find the newest driver, you may need to visit the Logitech website. It is a software utility which automatically finds and downloads the right driver. Tech Tip: If you are having trouble deciding which is the right driver, try the Logitech Driver Update Utility. In the results, choose the best match for your PC and operating system. Enter Logitech G602 into the search box above and then submit. If the driver listed is not the right version or operating system, search our driver archive for the correct version. Pros Comfortable Good button placement Impressive battery credentials Excellent, reliable tracking Cons Low max DPI Lacks bells and whistles Key Specifications Review Price: 59.99 Wireless mouse. After you complete your download, move on to Step 2. To get the G602 driver, click the green download button above. NOTE: Steps 1-3 may vary depending on the manufacturer.How to Update G602 Device Drivers Quickly & Easily Step 1 - Download Your Driver Computer mouse from a firm understood for making reliable peripherals. If you need help, see the Microsoft article How to determine whether a computer is running a 32-bit version or 64-bit version of Windows at The Logitech G602 Video Gaming Mouse is a powerful wireless video gaming. 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![]() ![]() Healthy range: 3.9 to 5.0 g/dL A/G ratio (albumin/globulin ratio) or total protein test Anything higher may indicate liver damage.Ī protein made by the liver, albumin levels can be an indicator of liver or kidney problems. When all’s well with your liver, your score on this test should be within range. This test looks at levels of the liver enzyme ALT. Chemistry Panel (or Metabolic Panel) ALT (alanine aminotransferase) Today, we have a wide range of testing options to choose from, with blood tests being among the most basic.ĭuring a physical examination, your doctor will often draw blood for chemistry and complete blood count (CBC) tests as well as a lipid profile, which measures cholesterol and related elements.īlood tests use the metric measurement system and abbreviations such as the following:īlood tests allow a doctor to see a detailed analysis of any disease markers, the nutrients and waste products in your blood as well as how various organs (e.g., kidneys and liver) are functioning.īelow, we’ve explained some of the commonly measured indicators of health. Not that long ago, doctors diagnosed patients through observation and the patients’ answers to questions. Why your doctor tests your bloodīlood tests, sometimes called blood panels, are one of a physician’s most basic tools. That way, the next time you have blood work done, you’ll be able to read the results like a pro. This below guide provides a brief explanation of the abbreviations used in measurements and descriptions of several common test components. So to empower our readers, here is a simplified guide to understanding your blood test results. If you’re interested in playing a more active role in your medical care-something we strongly recommend-then we suggest you save this. If you’re like most people, you’ve probably looked over the alphabet soup of acronyms and abbreviations in your blood test results and wondered what it all means. ![]() ![]() ![]() The city's Ohio History Center maintains a collection of artifacts from these cultures. The mound's clay was used in bricks for most of the city's initial brick buildings many were subsequently used in the Ohio Statehouse. The city's Mound Street derives its name from a mound that existed by the intersection of Mound and High Streets. Most of Central Ohio's remaining mounds are located outside of Columbus city boundaries, though the Shrum Mound is maintained, now as part of a public park and historic site. Remaining physical evidence of the cultures are their burial mounds and what they contained. and 1700 A.D., the Columbus metropolitan area was a center to indigenous cultures known as the Mound Builders, including the Adena, Hopewell and Fort Ancient peoples. ![]() Ancient and early history Shrum Mound, the feature of Campbell Memorial Parkīetween 1000 B.C. Nicknames for the city have included "the Discovery City", " Arch City", "Cap City", " Cowtown", "The Biggest Small Town in America" and "Cbus." Historyįor a chronological guide, see Timeline of Columbus, Ohio. Amid the George Floyd protests in 2020, several petitions pushed for the city to be renamed. Efforts to remove symbols related to the explorer in the city date to the 1990s. Since the late 20th century, historians have criticized Columbus for initiating the European conquest of America and for abuse, enslavement, and subjugation of natives. Although no reliable history exists as to why Columbus, who had no connection to the city or state of Ohio before the city's founding, was chosen as the name for the city, the book Columbus: The Story of a City indicates a state lawmaker and local resident admired the explorer enough to persuade other lawmakers to name the settlement Columbus. It is the largest city in the world named for the explorer, who sailed to and settled parts of the Americas on behalf of Isabella I of Castile and Spain. The city of Columbus was named after 15th-century Italian explorer Christopher Columbus at the city's founding in 1812. Fortune 500: Cardinal Health, American Electric Power, L Brands, Nationwide, Bread Financial and Huntington Bancshares.įurther information: § Italian-American community and symbols As of 2022, the Greater Columbus area is home to the headquarters of six corporations in the U.S. The metropolitan area is home to the Battelle Memorial Institute, the world's largest private research and development foundation Chemical Abstracts Service, the world's largest clearinghouse of chemical information and the Ohio State University, one of the largest universities in the United States. The city has a diverse economy based on education, government, insurance, banking, defense, aviation, food, clothes, logistics, steel, energy, medical research, health care, hospitality, retail and technology. The 1990s and 2000s saw redevelopment in numerous city neighborhoods, including Downtown. Beginning in the 1950s, Columbus began to experience significant growth it became the largest city in Ohio in land and population by the early 1990s. Amid steady years of growth and industrialization, the city has experienced numerous floods and recessions. The city assumed the function of state capital in 1816 and county seat in 1824. The city was named for Italian explorer Christopher Columbus. The city was founded in 1812 at the confluence of the Scioto and Olentangy rivers, and laid out to become the state capital. Franklinton, now a city neighborhood, was the first European settlement, laid out in 1797. It had a population of 2,138,926 in 2020, making it the largest metropolitan area entirely in Ohio and 14th-largest city in the U.S.Ĭolumbus originated as numerous Native American settlements on the banks of the Scioto River. It is the core city of the Columbus metropolitan area, which encompasses ten counties in central Ohio. Columbus is the county seat of Franklin County it also extends into Delaware and Fairfield counties. ![]() state capital after Phoenix, Arizona and Austin, Texas. With a 2020 census population of 905,748, it is the 14th-most populous city in the U.S., the second-most populous city in the Midwest after Chicago, and the third-most populous U.S. ![]() |
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